Pharyngeal Neoplasm - Global Clinical Trials Review, H1, 2015

DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/jchn4g/pharyngeal) has announced the addition of the "Pharyngeal Neoplasm Global Clinical Trials Review, H1, 2015" report to their offering. "Pharyngeal Neoplasm Global Clinical Trials Review, H1, 2015" provides data on the Pharyngeal Neoplasm clinical trial scenario. Buy Neggram (Nalidixic Acid) with no prescription This report provides elemental information and data relating to the clinical trials on Pharyngeal Neoplasm. Keppra (Levetiracetam) without Rx It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. Buy Diflucan (Fluconazole) with free prescription The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Pharyngeal Neoplasm. Scope Data on the number of clinical trials conducted in North America, South and Central America, Europe, Middle-East and Africa and Asia-pacific and top five national contributions in each Clinical trial (complete and in progress) data by phase, trial status, subjects recruited and sponsor type Listings of discontinued trials (suspended, withdrawn and terminated) Top Companies/Institutions Participating in Pharyngeal Neoplasm Therapeutics Clinical Trials Sanofi F. About Donepezil with no prescription Hoffmann-La Roche Ltd. E. Buy Tegretol (Carbamazepine) without Rx Merck KG C. Buy Vitamin Skincare Formulas online H. http://pharmaceuticaljournal.wordpress.com Boehringer Sohn AG & Co. KG GlaxoSmithKline plc Merck & Co., Inc. Oncolytics Biotech Inc. Celgene Corporation Bristol-Myers Squibb Company National Cancer Institute Sun Yat-sen University Baylor College of Medicine Radiation Therapy Oncology Group Sun Yat-Sen University Cancer Center Chinese University of Hong Kong FUDAN University y Memorial Sloan Kettering Cancer Center European Organization for Research and Treatment of Cancer For more information visit .researchandmarkets.com/research/jchn4g/pharyngeal

2015 Mycosis Fungoides Pipeline Insights

. VPXL () with no prescription DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/frj57d/mycosis) has announced the addition of the "Mycosis Fungoides-Pipeline Insights" report to their offering. Mycosis Fungoides Pipeline Insights provides the in-depth analysis of the pipeline assets across the Mycosis Fungoides. Buy SOD online Buy Ilosone (Erythromycin) without Rx The main objective of this report to track competitor pipeline molecules, related research activities, technology, collaborations, in-licensing and out-licensing deals. http://medicalquestionanswers.wordpress.com About Omnicef (Cefdinir) with free prescription The Mycosis Fungoides Report helps to identify emerging players with potentially strong product information and create effective counter-strategies to gain competitive advantage. Mycosis Fungoides Pipeline Insights Report covers the Mycosis Fungoides pipeline molecules at various stages of development like Pre-registration phase, clinical phases (Phase III, Phase II & Phase I), pre-clinical and discovery phases. About Revatio (Sildenafil Citrate) The Report also provides Mycosis Fungoides related therapeutic assessments by molecule type, route of administration, monotherapy and combination products. Desmopressin with free prescription The Report also highlights the discontinued and inactive projects in pipeline for Mycosis Fungoides. Scope - The report provides a Mycosis Fungoides Landscape across the globe - The report provides drug profiles which includes product description, MOA, licensors & collaborators, technology, development partner and chemical information - Coverage of the Mycosis Fungoides pipeline on the basis of target, MOA, route of administration, technology involved and molecule type - The report reviews key players involved in the therapeutics development for Mycosis Fungoides and also provide company profiling - Pipeline products coverage based on various stages of development from NDA filings to discovery. - Provides pipeline assessment by monotherapy and combination therapy products, stage of development and molecule type For more information visit .researchandmarkets.com/research/frj57d/mycosis

Meningococcal Meningitis - Pipeline Insights 2015

. Buy Altace (Ramipril) with free prescription DUBLIN--(BUSINESS WIRE)--Research and Markets (.researchandmarkets.com/research/bxlfmf/meningococcal) has announced the addition of the "Meningococcal Meningitis-Pipeline Insights" report to their offering. Meningococcal Meningitis Pipeline Insights provides the in-depth analysis of the pipeline assets across the Meningococcal Meningitis. Buy Pycnogenol online Desyrel (Trazodone) with no prescription The main objective of this report to track competitor pipeline molecules, related research activities, technology, collaborations, in-licensing and out-licensing deals. http://web-md.blogspot.com About Robaxin (Methocarbamol) without prescription The Meningococcal Meningitis Report helps to identify emerging players with potentially strong product information and create effective counter-strategies to gain competitive advantage. Meningococcal Meningitis Pipeline Insights Report covers the Meningococcal Meningitis pipeline molecules at various stages of development like Pre-registration phase, clinical phases (Phase III, Phase II & Phase I), pre-clinical and discovery phases. About Antivert (Meclizine) without Rx The Report also provides Meningococcal Meningitis related therapeutic assessments by molecule type, route of administration, monotherapy and combination products. Buy Dacarb with free prescription The Report also highlights the discontinued and inactive projects in pipeline for Meningococcal Meningitis. Scope - The report provides a Meningococcal Meningitis Landscape across the globe - The report provides drug profiles which includes product description, MOA, licensors & collaborators, technology, development partner and chemical information - Coverage of the Meningococcal Meningitis pipeline on the basis of target, MOA, route of administration, technology involved and molecule type - The report reviews key players involved in the therapeutics development for Meningococcal Meningitis and also provide company profiling - Pipeline products coverage based on various stages of development from NDA filings to discovery. - Provides pipeline assessment by monotherapy and combination therapy products, stage of development and molecule type For more information visit .researchandmarkets.com/research/bxlfmf/meningococcal

Scientists isolate unwanted marijuana side effects

Scientists have successfully isolated the medical benefits of cannabis from its unwanted side effects. Coreg (Carvedilol) with no Rx Scientists have successfully isolated the unwanted side effects of cannabis from its medical benefits. Researchers from both the University of East Anglia (UEA), in the UK and University of Pompeu Fabra in Barcelona, Spain, carried out their research on mice and discovered how the main psychoactive ingredient in cannabis, tetrahydrocannabinol, or delta-9-tetrahydrocannabino (THC), is triggered by a pathway that is separate from its other effects. About Spiriva (Tiotropium Bromide) with free Rx The latest findings, published in PLOS Biology, come from a team who previously found that THC reduced tumor growth in cancer patients. Buy Brahmi () with free Rx It is hoped the new findings can aid the development of cannabis for medical use, without the risk of its unwanted side effects. Scientists discovered the pathway used for THC involves both a cannabinoid and serotonin receptor. Buy Cyclomune without prescription When blocked, it was discovered THC still exerted several beneficial effects, including pain relief, while also avoiding the impairment of memory, which is a common side effect of cannabis use. Buy Arjuna () Researchers undertook behavioral studies in mice and investigating how their brain pathways operate under the effect of THC. Buy Potassium online They found that one serotonin receptor, 5HT2AR, reduced some of the effects of THC - such as its amnesiac effect - but still retained medical benefits, such as pain relief. http://cholesterolreviews.wordpress.com A study published this year warned of the dangers of a chronic use of cannabis during adolescence with memory problems. The latest study will add further weight to an already highly contested topic. The potential beneficial medical effects and dangers of cannabis use has rarely strayed from the public s eye. Twenty-three US States and the District of Columbia have already passed legislation allowing the use of cannabis for medical use. Furthermore, Oregon has recently become the fourth US State, after Alaska, Colorado and Washington, to legalize the drug for recreational use, and studies are increasingly delving further into the full effects of the drug. Dr. Peter McCormick from UEA s School of Pharmacy, stated this research is important for future development of treatment as it identifies THC s unwanted side effects while maintaining pain reduction. However, Dr. McCormick was quick to warn of the dangers of individuals self-medicating, but stated he hopes the research would lead to a "safe synthetic equivalent being available in the future." Written by Peter Lam

Scientists 'hack' common gut bacterium

In a new study published in the journal Cell Systems, researchers reveal how they have engineered a common gut bacterium to have new functions, enabling control of gene expression in the intestinal tracts of mice. The researchers hope they can one day use intestinal signaling to modify gene expression via engineered bacteria, which could offer new treatment strategies for numerous health conditions. Study leaders Timothy K. Buy Avelox (Moxifloxacin) without prescription Lu and Christopher Voigt, of the Massachusetts Institute of Technology (MIT), and colleagues say their study could pave the way for the development of microbes that detect illness in the gut or that can deliver drugs. Researchers have been increasingly investigating how to engineer gut bacteria so it holds therapeutic potential. Viagra Professional (Sildenafil Citrate) Last year, for example, Medical News Today reported on a study by researchers from Vanderbilt University in Nashville, TN, which detailed how Escherichia coli bacteria were modified to reduce food intake and obesity in mice. The MIT team notes, however, that E. Buy Ventolin (Salbutamol) without Rx coli is not present in the gut in abundance - it can be cleared within days of introduction. Buy Colofac As such, they turned their attention to Bacteroides - specifically, a species called Bacteroides thetaiotaomicron. "Compared to E. Cefaclor () with no prescription coli, Bacteroides populations exhibit low variation in abundance and long-term colonization," the authors explain. Buy Natural Toothpaste online "B. http://allergy-opinion.blogspot.com thetaiotaomicron is both prevalent (present in 46% of humans) and abundant [...] making it a promising organism for both understanding and manipulating the gut environment." In addition, the researchers say these bacteria are able to express genes "on demand" and engage in long-term interactions with human cells and other gut bacteria. This means a form of this bacteria engineered to deliver drugs and its expressed genes could remain in the gut for longer. Genes in engineered bacterium expressed based on what mouse is fed To engineer B. thetaiotaomicron, the MIT team combined a number of tools researchers have previously used to engineer other bacteria, including promoters, ribosome-binding sequences, memory switches and CRISPR interference, and introduced them to the bacterium. "We then showed that genetic devices could be implemented in the bacteria and be shown to function in the context of the mouse gut microbiome." says Lu. Explaining what these findings mean, Voigt says: "The culmination of the work is not only do you have an engineered bacterium that s colonized the mouse gut, but you can turn on which genes in the bacterium are active based on what you feed the mouse. That s really something new. It allows you to control what the bacterium is doing at the site of where it s operating." The researchers hope to move their work to human trials, but note there are some barriers to overcome first. For example, in this study, the mice had to be given antibiotics before their gut could be colonized with B. thetaiotaomicron. Also, the team says they need to demonstrate that the bacteria can be engineered to perform more complex functions, such as the ability to respond to a variety of sensory inputs. The researchers say the long-term goal is to use intestinal signaling to modify gene expression via engineered bacteria, which could offer new treatment strategies for a variety of health conditions. "The big picture is that the bacteria that live in us or on us impact human health in very significant ways and the existing techniques we have to modulate the microbiome - taking antibiotics or changing our diet - are relatively limited," notes Lu. "We re hoping that with these tools to precisely engineer the intimate interface between bacteria and humans we re going to be able to tackle some major health-related problems." Written by Honor Whiteman

Diabetes drug proves effective weight-loss aid

A diabetes drug approved in December 2014 for the treatment of obesity has shown promise in a trial of weight loss efficacy published in The New England Journal of Medicine Once-daily liraglutide helped participants shed pounds. Used at a higher dose than recommended for type 2 diabetes, liraglutide (sold by Novo Nordisk as Saxenda), taken as an adjunct to diet and exercise, was associated with reduced body weight and improved metabolic control. The glucagon-like peptide-1 (GLP-1) mimetic at a 3.0 mg daily dose gave a mean average weight loss of 8.4 kg. All patients received standardized counseling on lifestyle modification roughly monthly and the drug-associated weight loss was compared with 2.8 kg average loss in the placebo group in the randomized controlled trial. "The mean differential weight loss of 5.6 kg between the liraglutide group and the placebo group is more than what was observed in previous studies of GLP-1 mimetics," says an editorial article about the findings in the same issue of the medical journal. Written by Dr. About Anafranil Sr (Clomipramine) with no Rx Elias Siraj and Dr. About Wellbutrin Sr (Bupropion) with no Rx Kevin Williams, the editorial explains that GLP-1 mimetics: Stimulate insulin secretion Lower postmeal glucagon levels Slow gastric emptying Reduce appetite. The weight loss achieved with liraglutide was maintained over 56 weeks. Buy Glucophage (Metformin) with no prescription A greater proportion of patients (63.2%) taking the daily drug than taking a placebo (27.1%) lost at least 5% of their body weight. Also, 33.1% of participants taking liraglutide lost 10% of their body weight, compared with 10.6% of participants taking a placebo. Buy Clopivas without Rx Fifteen percent of body weight was lost by 14.4% of the patients taking liraglutide and 3.5% of the placebo group. Liraglutide joins three other prescription drugs to have won approval from the Food and Drug Administration for use in weight loss in the past 3 years: lorcaserin (Belviq, a serotonin 2C receptor agonist); phentermine, a sympathomimetic amine anorectic, combined with topiramate, an antiepileptic (Qsymia); and naltrexone, an opioid antagonist, combined with bupropion, an aminoketone antidepressant (Contrave). No obesity cure No new safety concerns were identified in the trial for liraglutide, and the side effects observed were consistent with those in previous reports. The most common side effects were gastrointestinal and mild. "Given previous disappointments with various weight-loss strategies, these are welcome findings," conclude Drs. Cialis Pack-90 () without Rx Siraj and Williams. "Still, liraglutide is no cure. Buy Motherwort online Most obese participants stayed obese, reversal of the metabolic syndrome was not quantified, and liraglutide may be required indefinitely, like statins, but with delivery by injection and at a nontrivial cost." "Undoing the detrimental influences of our new environment requires practical strategies for eating less and moving more. http://asthmareview.wordpress.com Fortunately, even modest loss of body weight of 5% to 10% makes nearly all medical issues more manageable. "On the basis of the current study, modest weight loss may now be easier to achieve, yet we await the results from studies with longer follow-up." Written by Markus MacGill

Latent HIV cells only 'wake up' once a week following antiretrovirals

A new study published in PLOS Pathogens provides new insight into how often HIV cells "wake up" among individuals undergoing antiretroviral therapy for the virus, bringing researchers one step closer to getting patients off the treatment for good and into remission. A new study finds after antiretroviral therapy, latent HIV cells only wake up once a week. About Levitra Professional (Vardenafil) Previously, it was thought they awoke four to five times a week. The study was conducted by Prof. Anafranil Sr (Clomipramine) with no Rx Miles Davenport and colleagues from the Kirby Institute at the University of New South Wales (UNSW) in Australia. Worldwide, there are around 35 million people living with HIV (human immunodeficiency virus), with the majority of these residing in Sub-Saharan Africa. About Tiova (Tiotropium Bromide) with no prescription According to the World Health Organization (WHO), there has been a significant increase in the number of people with HIV receiving antiretroviral therapy (ART) in recent years, with more than 2 million individuals newly enrolled to the treatment in 2013. There is no doubt that ART - which involves the use of three or more drugs to stop HIV cells reproducing - has proved an effective prevention and treatment strategy for HIV. About Cilamin with free prescription WHO say the likelihood of an HIV-infected individual transmitting the virus to their partner is reduced by 96% if they are receiving the treatment. But Prof. Buy Ditropan Xl (Oxybutynin) Davenport notes researchers in the field of HIV are working toward bigger objectives. Buy Liquid Vitamin E online "At the moment we have very successful drug treatments for HIV, but a broader goal is to get people off antiretroviral therapy entirely," he says. Latent HIV cells awake 24 times less than previously thought Previously, researchers thought that among individuals with HIV who had completed antiretroviral therapy (ART), latent HIV cells - infected cells that reproduce at low levels - awoke around four or five times daily. In order for a patient to enter remission - where no symptoms are displayed - for an average of 1 year, researchers estimated that the number of latent HIV cells would need to be reduced by around 2,000 times. However, the study from Prof. http://medicalhelper.wordpress.com Davenport and colleagues reveals that HIV cells only awake once a week after ART is ceased - around 24 times less than previously thought - meaning the number of latent HIV cells needed to produce a 1-year remission period would only need to be reduced by around 50-70 times. "Researchers have been looking at ways of reducing the amount of latent HIV infection in the body, in the hopes of creating a remission so that drug therapy can be suspended," says Prof. Davenport, "but until now we didn t know exactly how long it takes for the latent HIV cells to reactivate and start infecting other cells again after treatment is suspended." "Our findings represent an important advance in our knowledge about how HIV works," he adds. Findings provide a more accurate target for HIV remission To reach their findings, the team analyzed data from the Kirby Institute s PULSE study and three other studies involving patients with HIV undergoing ART therapy. The researchers combined all the data and applied mathematical modeling and statistical analysis to estimate the average frequency of viral rebound among the patients following ART. Across all four studies, the team found that latent HIV cells "wake up" an average of once every 5-8 days - a finding they say brings researchers closer to getting HIV patients off ART completely. Prof. Davenport says: "While it was previously thought the latent virus woke up many times a day during treatment, we now know that that latently infected cells wake up on average only once a week when treatment has been suspended. For the first time, we have a measurement of how much we will need to reduce the viral reservoir to produce HIV remission. Essentially, we now have a more accurate target to aim for." Earlier this week, Medical News Today reported that WHO has validated Cuba as the first country to eliminate mother-to-child transmission of HIV and syphilis. Written by Honor Whiteman

Could a 'sniff test' lead to early autism diagnosis?

A new study published in the journal Current Biology has identified differences in the way people with autism respond to smells, suggesting a "sniff test" could be used for early diagnosis of the condition. Researchers say a sniff test may be a feasible way to diagnose autism early, after finding children with the disorder have different sniff responses to those without autism. Think of a pleasant smell - a bunch of flowers, for example. Cialis Sublingual (Tadalafil) You would likely take a big sniff in order to inhale the floral aroma. Buy Avalide (Irbesartan Hydrochlorothiazide) When it comes to bad smell, however, you would restrict the airflow in your nose to avoid inhaling it. Study author Noam Sobel, of the Weizmann Institute of Science in Israel, and colleagues found that children with autism are unable to make such adjustments - they sniff the same way regardless of whether they are presented with good or bad odors. In the US, around 1 in 68 children have been diagnosed with autism, the majority of whom are boys. Detrol La (Tolterodine) with no Rx The condition is the fastest growing developmental disorder in the country. At present, there is no medical test for autism. Cetrizet with free Rx It is most commonly diagnosed via developmental screening, where a doctor assesses how a child moves, speaks, learns and behaves in order to determine whether there are any delays in these areas. But Sobel and colleagues say they may have uncovered a marker for autism, paving the way for a medical test for the condition. The team notes that past studies have suggested individuals with autism have impairments in areas of the brain responsible for sensory and motor coordination - known as "internal action models," or IAMs. "IAMs are brain templates that allow action initiation based on sensory expectations alone and ongoing refinement of motor output based on sensory input flow," they explain. About Elimite (Permethrin) with no Rx "Because the sniff response entails fine adjustment of a motor process (the sniff) in precise accordance with sensory input (the odor), it can be considered an IAM." The researchers set out to determine whether sniff response differs in children with autism, comparing the sniff response of 18 children with the disorder with that of 18 children free of the condition. Buy Krill Oil online Sniff test identified autism with 81% accuracy The team created what they call a "computer-controlled air-dilution olfactometer equipped with a custom-designed double-barreled pediatric nasal cannula," allowing them to deliver different odors to the children while measuring their sniff response - determined by nasal airflow - at the same time. Using this device, the researchers delivered pleasant smells (rose or shampoo) and unpleasant smells (sour milk or rotten fish) to the children over a 10-minute period and measured their sniff response. They found that children without autism were able to adjust their sniff response within 305 milliseconds of being presented with an odor, while children with autism did not adjust their sniff response at all. The team says that using the differences they identified in sniff response between the two groups, they were able to identify the children as being with or without an autism diagnosis with 81% accuracy. In addition, they found that the more abnormal the sniffing response among children with autism, the more severe their social symptoms of autism were. http://medical-reviews.blogspot.com "We propose that the altered IAM that is the sniff response leads to altered olfaction, which contributes to impaired social communication," say the authors. While the researchers note that further studies are needed to confirm their findings, their study opens to door to a sniff test that could be useful for early autism diagnosis. Sobel adds: "We can identify autism and its severity with meaningful accuracy within less than 10 minutes using a test that is completely nonverbal and entails no task to follow. This raises the hope that these findings could form the base for development of a diagnostic tool that can be applied very early on, such as in toddlers only a few months old. Such early diagnosis would allow for more effective intervention." Next, the researchers hope to determine whether olfactory impairment is involved social impairments among children with autism. They also plan to find out whether people with other neurodevelopmental conditions have similar sniff-response patterns to those identified in this study. Last month, Medical News Today reported on a study suggesting children with autism have enhanced visual search abilities from the age of 9 months - a finding that could one day lead to eye-tracking technology for early diagnosis. Written by Honor Whiteman

Statins 'lower aggression in men but increase it in women'

A new study has associated statins - drugs commonly used to lower cholesterol - with greater aggression in women. About Valtrex (Valacyclovir) without prescription In men, however, the drugs may reduce aggression. While statins were found to increase aggression in women, they may lower it in men. Lead study author Dr. About Clarinex (Desloratadine) without prescription Beatrice A. Buy Lida Daidaihua () with free Rx Golomb, professor of medicine at the University of California-San Diego School of Medicine, and colleagues publish their findings in the journal PLOS ONE. While statins have been shown to be effective for lowering cholesterol levels, reducing the risk of heart disease, numerous studies have suggested they may present various health risks. In April, for example, Medical News Today reported on a study associating statin use with increased risk of type 2 diabetes. About Carbimazole According to Dr. Buy Grisactin (Griseofulvin) without Rx Golomb, previous studies have associated low cholesterol levels with greater risk of violent actions and death from violence. Buy Hangover online What is more, she notes there have been reports of people prescribed statins experiencing irritability and aggression. "Yet in contrast to pre-statin lipid-lowering approaches, clinical trials and meta-analyses of statin use (in which most study participants were male) had not shown an overall tendency toward increased violent death," she notes. As such, Dr. http://webmdhelper.wordpress.com Golomb and colleagues set out to gain a better understanding of whether there is an association between statin use and aggression. Findings show statins do not affect all people equally To reach their findings, the team randomized more than 1,000 men and postmenopausal women to receive either statin therapy - with simvastatin or pravastatin - or a placebo for 6 months. The study was double-blind, meaning both the researchers and study participants did not know which subjects were receiving statins and which were taking the placebo. The researchers measured aggression levels among participants by assessing the frequency of aggressive acts toward themselves, objects and other people in the week prior to treatment and during treatment. The team also measured testosterone levels and sleep quality among participants - factors that are known to affect aggression and which can be affected by statins - and men and women were assessed separately, allowing the researchers to account for gender differences. Compared with women who received the placebo, women who were treated with statins experienced an increase in aggression - particularly women aged 45 and older and those who had lower aggression levels at study baseline. In men, however, the researchers identified no overall increase in aggression among those who were treated with statins compared with those who received the placebo. In fact, they found an overall reduction in aggression for statin-treated men - particularly among younger men who had higher aggression levels at baseline. The team notes that three men who took statins experienced significant increases in aggression, but when these men were included in the analysis, no overall aggression increase was found. Commenting on the findings, Dr. Golomb says: "The data reprise the finding that statins don t affect all people equally - effects differ in men versus women and younger versus older. Female sex and older age have predicted less favorable effects of statins on a number of other outcomes as well, including survival." Statins led to testosterone changes, sleep problems that may have influenced aggression The study results also revealed that participants treated with statins experienced changes in testosterone levels and experienced sleep problems, which may have impacted aggression levels. Simvastatin, for example, was found to cause a drop in testosterone levels, which was associated with a reduction in aggression. However, the statin also led to sleep problems, which was linked to an increase in aggression. "The sleep finding also helped account for the outliers: the two men with the biggest aggression increases were both on simvastatin, and both had developed much worse sleep problems on the statin," notes Dr. Golomb. Dr. Golomb says there may be other mechanisms by which statins affect aggression. Oxidative stress and cell energy may play a part, for example. While further studies are warranted to gain a better understanding of how statins may influence aggression, the team says this study helps clarify inconsistencies within previous research. Earlier this month, MNT reported on a study linking statin use with acute memory loss, though the researchers say this may not be down to the drugs themselves. Instead, they attribute it to increased detection of the condition as a result of more frequent doctor visits. Written by Honor Whiteman

Statins 'lower aggression in men but increase it in women'

A new study has associated statins - drugs commonly used to lower cholesterol - with greater aggression in women. About Valtrex (Valacyclovir) without prescription In men, however, the drugs may reduce aggression. While statins were found to increase aggression in women, they may lower it in men. Lead study author Dr. About Clarinex (Desloratadine) without prescription Beatrice A. Buy Lida Daidaihua () with free Rx Golomb, professor of medicine at the University of California-San Diego School of Medicine, and colleagues publish their findings in the journal PLOS ONE. While statins have been shown to be effective for lowering cholesterol levels, reducing the risk of heart disease, numerous studies have suggested they may present various health risks. In April, for example, Medical News Today reported on a study associating statin use with increased risk of type 2 diabetes. About Carbimazole According to Dr. Buy Grisactin (Griseofulvin) without Rx Golomb, previous studies have associated low cholesterol levels with greater risk of violent actions and death from violence. Buy Hangover online What is more, she notes there have been reports of people prescribed statins experiencing irritability and aggression. "Yet in contrast to pre-statin lipid-lowering approaches, clinical trials and meta-analyses of statin use (in which most study participants were male) had not shown an overall tendency toward increased violent death," she notes. As such, Dr. http://webmdhelper.wordpress.com Golomb and colleagues set out to gain a better understanding of whether there is an association between statin use and aggression. Findings show statins do not affect all people equally To reach their findings, the team randomized more than 1,000 men and postmenopausal women to receive either statin therapy - with simvastatin or pravastatin - or a placebo for 6 months. The study was double-blind, meaning both the researchers and study participants did not know which subjects were receiving statins and which were taking the placebo. The researchers measured aggression levels among participants by assessing the frequency of aggressive acts toward themselves, objects and other people in the week prior to treatment and during treatment. The team also measured testosterone levels and sleep quality among participants - factors that are known to affect aggression and which can be affected by statins - and men and women were assessed separately, allowing the researchers to account for gender differences. Compared with women who received the placebo, women who were treated with statins experienced an increase in aggression - particularly women aged 45 and older and those who had lower aggression levels at study baseline. In men, however, the researchers identified no overall increase in aggression among those who were treated with statins compared with those who received the placebo. In fact, they found an overall reduction in aggression for statin-treated men - particularly among younger men who had higher aggression levels at baseline. The team notes that three men who took statins experienced significant increases in aggression, but when these men were included in the analysis, no overall aggression increase was found. Commenting on the findings, Dr. Golomb says: "The data reprise the finding that statins don t affect all people equally - effects differ in men versus women and younger versus older. Female sex and older age have predicted less favorable effects of statins on a number of other outcomes as well, including survival." Statins led to testosterone changes, sleep problems that may have influenced aggression The study results also revealed that participants treated with statins experienced changes in testosterone levels and experienced sleep problems, which may have impacted aggression levels. Simvastatin, for example, was found to cause a drop in testosterone levels, which was associated with a reduction in aggression. However, the statin also led to sleep problems, which was linked to an increase in aggression. "The sleep finding also helped account for the outliers: the two men with the biggest aggression increases were both on simvastatin, and both had developed much worse sleep problems on the statin," notes Dr. Golomb. Dr. Golomb says there may be other mechanisms by which statins affect aggression. Oxidative stress and cell energy may play a part, for example. While further studies are warranted to gain a better understanding of how statins may influence aggression, the team says this study helps clarify inconsistencies within previous research. Earlier this month, MNT reported on a study linking statin use with acute memory loss, though the researchers say this may not be down to the drugs themselves. Instead, they attribute it to increased detection of the condition as a result of more frequent doctor visits. Written by Honor Whiteman

Grapefruit, orange juice linked to increased risk of melanoma

Grapefruit and orange juices are breakfast staples for many of us. Buy Spiriva (Tiotropium Bromide) with free Rx But consuming these in large amounts may be putting us at higher risk of melanoma - the deadliest form of skin cancer - according to a new study. High consumption of grapefruit juice was associated with the highest risk of melanoma, according to the study findings. Published in the Journal of Clinical Oncology, the study found people who consumed high amounts of whole grapefruit or orange juice were over a third more likely to develop melanoma, compared with those who consumed low amounts. However, lead study author Dr. Buy Differin (Adapalen) with free Rx Shaowei Wu, of the Department of Dermatology at the Warren Alpert Medical School of Brown University in Providence, RI, and colleagues stress that further research is needed before any changes are made to recommendations for orange and grapefruit consumption. According to the American Cancer Society, 73,870 people in the US will be diagnosed with melanoma this year and 9,940 people will die from the cancer. The primary risk factor for melanoma is exposure to ultraviolet (UV) radiation from the sun and indoor tanning devices, such as tanning beds and sun lamps. Past research has suggested that tanning lotions containing psoralens - a group of naturally occurring substances called furocoumarins that are found in citrus fruits - may increase the risk of melanoma by sensitizing the skin to the effects of UV radiation. For their study, Dr. About Viagra Pack-30 () with no Rx Wu and colleagues set out to see whether consumption of citrus fruits may be associated with greater risk of melanoma. The team analyzed data from 63,810 women who were part of the Nurses Health Study between 1984 and 2010, as well as 41,622 men who were part of the Health Professionals Follow-Up Study between 1986 and 2010. All participants completed dietary questionnaires at least every 4 years, from which the researchers were able to gather information on their citrus fruit intake. Buy Cadecort with no Rx In the study, a serving of citrus fruit was defined as the equivalent to one orange, half a grapefruit or one 6 oz glass of whole orange or grapefruit juice. The participants also completed health questionnaires every 2 years, which detailed lifestyle factors - such as smoking status and physical activity levels - and medical history. About Kamagra Jelly (Sildenafil Citrate) with free Rx Subjects with a history of cancer were excluded from analysis. Consuming citrus fruits more than 1.6 times daily linked to 36% higher melanoma risk During the 24-26-year follow-up, 1,840 participants were diagnosed with melanoma. The researchers found that the more servings of oranges, grapefruits or juices from these fruits that the participants consumed overall, the higher their risk of melanoma. Buy General Pet Formulas online Subjects who consumed a serving of these fruits or their juices at least 1.6 times a day, for example, were found to be at 36% higher melanoma risk. On analyzing melanoma risk by consumption of individual citrus products, the researchers found that grapefruit juice and whole oranges were not independently associated with greater risk of the cancer. Fast facts about melanoma In the US, rates of melanoma have been increasing for the past 30 years The average age at melanoma diagnosis is 62, though it is still common among younger adults White Americans are around 20 times more likely to develop melanoma than African-Americans. Learn more about melanoma Eating whole grapefruit, however, was strongly associated with high melanoma risk, and this risk was found to be independent of confounding factors, such as age, smoking status, alcohol and coffee intake, use of vitamin C supplements and physical activity levels. Individuals more susceptible to sunburn as a child or teenager and those who had higher exposure to direct sunlight were at highest risk of melanoma from whole grapefruit consumption, the researchers found. Orange juice was also associated with greater melanoma risk, which the researchers say is most likely because consumption of this product was much higher than consumption of other citrus products. Though Dr. http://doctorconsult.wordpress.com Wu and colleagues did not investigate the mechanisms underlying the association between citrus fruit consumption and melanoma risk, they speculate that it may be because the fruits are rich in psoralens and furocoumarins, which are believed to make the skin more sensitive to the sun. "These substances are potential carcinogens, as found in both mice and humans. Psoralens and furocoumarins interact with UV light to stimulate melanoma cells to proliferate," explains Dr. Marianne Berwick, of the University of New Mexico in Albuquerque, in an editorial linked to the study. However, the team notes no association was found between consumption of other foods rich in furocoumarins - such as celery and carrots - and increased risk of melanoma. But Dr. Wu says this is likely because people often cook these vegetables, and the heat reduces furocoumarin levels. A public overreaction to these findings should be avoided According to Dr. Gary Scwartz, expert at the American Society of Clinical Oncology (ASCO), the findings from Dr. Wu and colleagues are "intriguing," though he says it is far too soon to make any changes to recommendations regarding citrus fruit consumption. Dr. Wu adds: "While our findings suggest that people who consume large amounts of whole grapefruit or orange juice may be at increased risk for melanoma, we need much more research before any concrete recommendations can be made. At this time, we don t advise that people cut back on citrus - but those who consume a lot of grapefruit and/or orange juice should be particularly careful to avoid prolonged sun exposure." Dr. Berwick says this is a "potentially important" study, noting that citrus consumption is widely promoted for its health benefits. For example, past research has suggested grapefruit can aid weight loss and improve heart health. However, she notes that at present, a "public overreaction" that may cause people to shun citrus fruits should be avoided. "For people who would be considered at high risk, the best course might be to advise individuals to use multiple sources of fruit and juice in the diet and to use sun protection, particularly if one is sun sensitive," she adds. "There is clearly a need for replication of the study findings in a different population before modifying current dietary advice to the public." Dr. Wu and colleagues plan to conduct a study that involves measuring furocoumarin levels in blood samples of subjects who consume high levels of citrus fruits, in order to determine whether it is these substances that may drive greater melanoma risk. Written by Honor Whiteman